Investigation of Neuroprotective and Therapeutic Effects of Hesperidin in Experimental Spinal Cord Injury.
RatSpinal cord injuryContusionWistar albinoMalen = 32 rats in four groupsPreconditioning group treated before injury; treatment group treated after inju…
Model: Weight-drop spinal cord injury, 100 g/cm onto cord exposed at T7 to T10 by dorsal laminectomy
Hesperidin improved neurological scores at 24 hours, lowered IL-1beta and TNF-alpha, raised total antioxidant status, reduced haemorrhage, laceration, axonal and neuronal degeneration, necrosis, inflammation and oedema, and reduced caspase-3 positive apoptotic cells in both preconditioning and trea…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.