Mesenchymal Stem Cells Application in Wound Tissue Healing in Old Animals.
RatWoundWistar (white Wistar)malen = 80 rats in total; 5 groups x 3 euthanasia points, 7 wounds…Local intradermal injection into wound edges (SC group); topical application in polymer hydrogel (Polymer_sc group)Injection group: 0.1 mL into lateral edge plus 0.1 mL into…Same day as wound modelling (day 0)
Model: Two standardised square full-thickness excisional back skin wounds (deep to muscle fascia), initial area 135.8 mm2, under chloral hydrate anaesthesia (300 mg/kg i.p.)
Both local injection and topical hydrogel delivery of mesenchymal stem cells accelerated healing, with the polymer hydrogel most effective. On day 14 the Polymer_sc wound area was 8.5 mm2, 16.73 times smaller than day 0 (p<0.001), while Control_0 wounds were 2.60 times larger (p=0.004) and SC wound…
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