THERAPY DOSSIER · th-02fd2f09ec5f

Human umbilical cord mesenchymal stem cells, injected or delivered in a chitosan/alginate/agar/pectin polymer hydrogel

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07580755 ↗Injury indicationNArecruiting

A Randomized Controlled Study on the Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cells in the Treatment of Extensive Burns

Burn Injury · Burn Patients

Enrolment: 90 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33204113 ↗2020Reported benefit

Mesenchymal Stem Cells Application in Wound Tissue Healing in Old Animals.

RatWoundWistar (white Wistar)malen = 80 rats in total; 5 groups x 3 euthanasia points, 7 wounds…Local intradermal injection into wound edges (SC group); topical application in polymer hydrogel (Polymer_sc group)Injection group: 0.1 mL into lateral edge plus 0.1 mL into…Same day as wound modelling (day 0)

Model: Two standardised square full-thickness excisional back skin wounds (deep to muscle fascia), initial area 135.8 mm2, under chloral hydrate anaesthesia (300 mg/kg i.p.)

Both local injection and topical hydrogel delivery of mesenchymal stem cells accelerated healing, with the polymer hydrogel most effective. On day 14 the Polymer_sc wound area was 8.5 mm2, 16.73 times smaller than day 0 (p<0.001), while Control_0 wounds were 2.60 times larger (p=0.004) and SC wound…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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