Low-intensity ultrasound combined with allogenic adipose-derived mesenchymal stem cells (AdMSCs) in radiation-induced skin injury treatment.
Guinea pigRadiationHartley Dunkinfemalen = n=42 treated animals, 6 per group across 7 groups; plus n=5…Intradermal injection of cells; ultrasound applied externally to skin2 x 10^6 cells transplanted; ultrasound 40 kHz at mechanica…Cells transplanted 24 h after 60 Gy irradiation; ultrasound priming of cells 24…
Model: Acute radiation skin injury induced by 60 Gy from a 6 MV linear accelerator at 2 Gy/min, 100 cm source to skin distance, 3 x 3 cm field, to clamped abdominal skin
Radiation injury score was significantly lower in the ultrasound-primed cell groups from day 14 to 18 versus control, sham and ultrasound alone (p<0.05). Lowest total skin thickness was in the ultrasound-primed cell group at 1.25 +/- 0.08 mm versus sham 1.92 +/- 0.07 mm and healthy skin 0.89 +/- 0.…
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