THERAPY DOSSIER · th-4e7b7b5f1675

Allogeneic adipose-derived mesenchymal stem cells, alone and combined with 40 kHz low-intensity ultrasound

Biologic · Allogeneic adipose-derived mesenchymal stem cells +/- low-intensity ultrasound; cell therapy (specific combination not found in trials).

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Allogeneic adipose-derived mesenchymal stem cells +/- low-intensity ultrasound; cell therapy (specific combination not found in trials).
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33203925 ↗2020Reported benefit

Low-intensity ultrasound combined with allogenic adipose-derived mesenchymal stem cells (AdMSCs) in radiation-induced skin injury treatment.

Guinea pigRadiationHartley Dunkinfemalen = n=42 treated animals, 6 per group across 7 groups; plus n=5…Intradermal injection of cells; ultrasound applied externally to skin2 x 10^6 cells transplanted; ultrasound 40 kHz at mechanica…Cells transplanted 24 h after 60 Gy irradiation; ultrasound priming of cells 24…

Model: Acute radiation skin injury induced by 60 Gy from a 6 MV linear accelerator at 2 Gy/min, 100 cm source to skin distance, 3 x 3 cm field, to clamped abdominal skin

Radiation injury score was significantly lower in the ultrasound-primed cell groups from day 14 to 18 versus control, sham and ultrasound alone (p<0.05). Lowest total skin thickness was in the ultrasound-primed cell group at 1.25 +/- 0.08 mm versus sham 1.92 +/- 0.07 mm and healthy skin 0.89 +/- 0.…

Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.

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