Opioid Preconditioning Modulates Repair Responses to Prevent Renal Ischemia-Reperfusion Injury.
RatIschaemia-reperfusionRenalWistarmalen = 24 rats; n=6 per group (sham, ischaemia-reperfusion, ischae…IntraperitonealMorphine 0.5 mg/kg; fentanyl 10 micrograms/kg1 h (60 min) before the ischaemic surgical procedure
Model: Unilateral renal ischaemia-reperfusion by microvascular clamping of the left renal hilum for 45 min followed by 24 h reperfusion, under xylazine 8 mg/kg i.p. and ketamine 100 mg/kg i.p.
Ischaemia-reperfusion raised serum creatinine to 1.038 +/- 0.0606 mg/dL versus 0.460 +/- 0.0287 mg/dL in sham (p<0.001); preconditioning lowered it to 0.613 +/- 0.0324 mg/dL with morphine (p=0.002) and 0.562 +/- 0.0517 mg/dL with fentanyl (p<0.001), and prevented KIM-1 induction. HIF-1alpha mRNA ro…
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