Intraoperative ketamine on opioid consumption and pain after spine surgery in opioid-dependent patients
Postoperative Pain · Chronic Pain · Analgesics
Enrolment: 147 · Results not recorded
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Drug · Mu opioid receptor agonist (AGONIST), direct interaction, disease efficacy true.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Postoperative Pain · Chronic Pain · Analgesics
Enrolment: 147 · Results not recorded
Pain, Postoperative
Enrolment: 10 · Results not recorded
Pain, Postoperative
Enrolment: 17 · Results not recorded
Pain · Sickle Cell Disease
Enrolment: 31 · Results not recorded
Heart Diseases
Enrolment: 3 · Results not recorded
Pain
Enrolment: 31 · Results not recorded
Osteoarthritis of the Knee
Enrolment: 157 · Results not recorded
Hallux Valgus
Enrolment: 187 · Results not recorded
Postoperative Nausea and Vomiting
Enrolment: 27034 · Results not recorded
Analgesia Post Craniotomy
Enrolment: 60 · Results not recorded
Pancreatitis, Acute
Enrolment: 44 · Results not recorded
Cesarean Section · Post Operative Pain
Enrolment: 52 · Results not recorded
Opioid Use
Enrolment: 60 · Results not recorded
Pain, Postoperative · Anesthesia · Analgesia
Enrolment: 115 · Results not recorded
Postoperative Pain
Enrolment: 40 · Results not recorded
Gynecological; Surgery (Previous), Affecting Fetus or Newborn, Due to Obstructed Labor · Analgesia
Enrolment: 119 · Results not recorded
Arthroplasty, Replacement, Hip
Enrolment: 18 · Results not recorded
Post Operative Pain
Enrolment: 44 · Results not recorded
12 studies reported at therapy level; 12 evidence entries itemised.
Model: Extremity trauma induced under isoflurane anaesthesia by clamping retrofemoral tissues of one hindlimb for 30 seconds followed by closed fibula fracture, with no fixation surgery
After extremity trauma, paw withdrawal latency, paw withdrawal pressure and weight bearing fell by 61 plus or minus 4%, 64 plus or minus 8% and 65 plus or minus 4% respectively and remained depressed for 3 to 4 hours. Opioids increased paw withdrawal latency for at least 80 minutes, with sufentanil…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.82. Machine-extracted fields require source verification.
Model: Unilateral renal ischaemia-reperfusion by microvascular clamping of the left renal hilum for 45 min followed by 24 h reperfusion, under xylazine 8 mg/kg i.p. and ketamine 100 mg/kg i.p.
Ischaemia-reperfusion raised serum creatinine to 1.038 +/- 0.0606 mg/dL versus 0.460 +/- 0.0287 mg/dL in sham (p<0.001); preconditioning lowered it to 0.613 +/- 0.0324 mg/dL with morphine (p=0.002) and 0.562 +/- 0.0517 mg/dL with fentanyl (p<0.001), and prevented KIM-1 induction. HIF-1alpha mRNA ro…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
Model: Hindpaw plantar surgical incision under isoflurane anaesthesia
Incision impaired attentional performance, raising area under the median cue duration-time curve to 97.2 (SD 56.8) s-days versus 25.5 (SD 14.5) s-days for anaesthesia control. Morphine 1 mg/kg reduced this impairment to 31.6 (SD 36.7) s-days versus 110.0 (SD 64.7) s-days with saline, and the morphi…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Hindpaw plantar incision (surgical) injury at postnatal day 3
Neonatal plantar incision produced mechanical hypersensitivity resolving within 24 hours, but in adolescence male rats showed ipsilaterally restricted mechanical, heat and cold hypersensitivity and social behavioural deficits, whereas females did not. Neonatal injury did not alter acute morphine an…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Midline T9 contusion spinal cord injury at 150 kDyn (1 s dwell) or 200 kDyn, and unilateral T13 contusion at 100 kDyn
Contusion injury produced mechanical allodynia (males only in the 150 kDyn midline model) and thermal hyperalgesia, but the early post-trauma course of morphine did not significantly amplify chronic neuropathic pain in any model.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: spinal contusion (T12) injury
Intravenous morphine after spinal contusion injury caused near-complete loss of NeuN positive neurons at the lesion, decreased astrocyte (GFAP) and microglial (OX-42) marker expression, attenuated locomotor recovery, decreased weight gain and induced opioid-induced hyperalgesia, indicating morphine…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.
Model: Hindpaw plantar incision under 1.5-2.0% isoflurane: 5 mm longitudinal incision through skin and fascia starting 2 mm from the proximal edge of the heel, underlying muscle elevated with curved forceps leaving origin and insertion intact, skin apposed with a single 8-0 nylon mattress suture removed at the end of postoperative day 2
Morphine 10 ug given in the early phase attenuated mechanical hyperalgesia on postoperative days 7, 12 and 14 (F(4,245)=12.23, p<0.0001) and this was reversed by naloxone, whereas late-phase morphine had no effect (F(3,112)=0.20, p=0.89). Morphine reduced M1 macrophages (F(2,30)=22.65, p<0.0001), i…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Moderate spinal contusion injury
Contused animals took less morphine in the acute phase but at 14 and 35 days took nearly all available morphine, with significant weight loss and no effect on locomotor recovery, indicating addictive potential is not reduced after injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: 0.4 mm femoral osteotomy gap with operative stabilisation
Morphine significantly reduced callus strength at 8 weeks (p = 0.048) and inhibited callus resorption and remodelling, with only a 13% fall in callus volume between 4 and 8 weeks (p = 0.393) compared with a 29% fall in controls (p = 0.023).
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Contusion spinal cord injury
Contusion injury significantly increased conditioned place preference expression relative to sham and intact controls in the acute phase. Contused animals self-administered significantly less morphine than sham and intact controls, but the effect was dose-dependent: at a high concentration injured…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Closed tibial fracture producing severe acute nociceptive traumatic pain in mice previously given a chronic high dose of buprenorphine that induced mechanical allodynia
Chronic high dose buprenorphine produced significant mechanical allodynia. After closed tibial fracture, morphine at 4.5 mg/kg, a dose that is analgesic in untreated animals, failed to reduce pain in the buprenorphine group. Combining the same dose of morphine with ketamine or with ketoprofen resto…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Complete transverse section of the spinal cord at T8-T9 under deep isoflurane anaesthesia with absorbable haemostatic gel foam inserted; sham animals underwent laminectomy only
Transection produced sustained at-level mechanical and cold allodynia with a 100-fold lower pressure threshold than sham, hindpaw hyper-reflexia and prolonged upregulation of neuronal injury and glial activation transcripts. Morphine 3 to 10 mg/kg, tapentadol 20 mg/kg and ketamine 50 mg/kg raised t…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.