African Vegetables (Leaf and Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats.
RatChemical/toxinWistar albinomalen = 7 groups of 7 rats per groupOral400 mg/kg/day of each extract; positive control vitamin C 2…3 hours before each daily trastuzumab dose
Model: Cardiotoxicity induced by repeated daily intraperitoneal trastuzumab 2.25 mg/kg/day for 7 days
Trastuzumab significantly increased serum LDH and cardiac troponin I (p<0.0001), suppressed cardiac SOD, CAT and GST activities and GSH, elevated GPx and MDA, and produced vascular congestion, intraparenchymal haemorrhage and coronary artery microthrombi. Oral pretreatment with 400 mg/kg/day of eit…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.