THERAPY DOSSIER · th-15becd727f75

Ethanol leaf extract (CVE, Clerodendrum volubile) and ethanol seed extract (IGE, Irvingia gabonensis), dissolved in 5% DMSO in sterile water

Nutraceutical · Crude botanical extracts; no defined ChEMBL entity. No ClinicalTrials.gov record for Clerodendrum volubile; Irvingia gabonensis appears in weight-management trials unrelated to this indication, so no trial retained.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Crude botanical extracts; no defined ChEMBL entity. No ClinicalTrials.gov record for Clerodendrum volubile; Irvingia gabonensis appears in weight-management trials unrelated to this indication, so no trial retained.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33178389 ↗2020Reported benefit

African Vegetables (Leaf and Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats.

RatChemical/toxinWistar albinomalen = 7 groups of 7 rats per groupOral400 mg/kg/day of each extract; positive control vitamin C 2…3 hours before each daily trastuzumab dose

Model: Cardiotoxicity induced by repeated daily intraperitoneal trastuzumab 2.25 mg/kg/day for 7 days

Trastuzumab significantly increased serum LDH and cardiac troponin I (p<0.0001), suppressed cardiac SOD, CAT and GST activities and GSH, elevated GPx and MDA, and produced vascular congestion, intraparenchymal haemorrhage and coronary artery microthrombi. Oral pretreatment with 400 mg/kg/day of eit…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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