Ameliorative effects and mechanism of crocetin in arsenic trioxide-induced cardiotoxicity in rats.
RatChemical/toxinSprague-Dawleymalen = 40 rats; n=10 per group across four groupsIntraperitoneal20 mg/kg (CRT-L) and 40 mg/kg (CRT-H)6 h before each daily arsenic trioxide dose
Model: Cardiotoxicity induced by intraperitoneal arsenic trioxide 5 mg/kg daily over 10 days
Arsenic trioxide significantly increased heart rate and J-point elevation, serum creatine kinase and LDH, cardiac ROS, MDA and the inflammatory and pro-apoptotic markers, and decreased SOD, GSH-Px, CAT, Bcl-2 and SirT1 (all p<0.01 versus control). Crocetin at 20 and 40 mg/kg reversed these changes…
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