Phase 3 study of TSC with radiotherapy and temozolomide in biopsy-only glioblastoma
Glioblastoma
Enrolment: 19 · Results not recorded
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Nutraceutical
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Glioblastoma
Enrolment: 19 · Results not recorded
Glioblastoma · GBM · Glioma
Enrolment: 59 · Results not recorded
Stroke, Acute
Enrolment: 6 · Results not recorded
Interstitial Lung Disease
Enrolment: 18 · Results not recorded
SARS-CoV-2 (Covid19)
Enrolment: 25 · Results not recorded
Intermittent Claudication
Enrolment: 48 · Results not recorded
Healthy Subjects
Enrolment: 30 · Results not recorded
Healthy Volunteers With Induced Hypoxia
Enrolment: 30 · Results not recorded
High Grade Glioma
Enrolment: 1 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Cardiotoxicity induced by intraperitoneal arsenic trioxide 5 mg/kg daily over 10 days
Arsenic trioxide significantly increased heart rate and J-point elevation, serum creatine kinase and LDH, cardiac ROS, MDA and the inflammatory and pro-apoptotic markers, and decreased SOD, GSH-Px, CAT, Bcl-2 and SirT1 (all p<0.01 versus control). Crocetin at 20 and 40 mg/kg reversed these changes…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Cerebral contusion (traumatic brain injury)
Crocetin improved neurological recovery after cerebral contusion in rats by inhibiting neuronal apoptosis and promoting angiogenesis.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.