Mechanisms underlying the protective effect of tannic acid against arsenic trioxide-induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis.
RatChemical/toxinSprague-DawleyMalen = 50 adult male rats allocated to five groupsIntragastric administration20 mg/kg/day (low dose) and 40 mg/kg/day (high dose); a 40…Concurrent with injury induction: tannic acid given every morning and arsenic t…
Model: Arsenic trioxide-induced cardiotoxicity, produced by intraperitoneal injection of arsenic trioxide 5 mg/kg/day for 7 days
Both tannic acid doses preserved near-normal myocardial architecture, significantly lowered serum creatine kinase and lactate dehydrogenase, reduced myocardial reactive oxygen species and malondialdehyde, restored superoxide dismutase and catalase activity, and reduced cytochrome c, Smac, HtrA2, Ba…
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