Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Chemical/toxin
- Reported indication
- Not recorded
- First approval
- 1982
- Development stage
- Not recorded
- ChEMBL max phase
- 4 / 4 (development scale, not regulatory approval)
- Synonyms
- Gallotannic acid; Gallotannin; E181; Tannicum acidum
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatChemical/toxinSprague-DawleyMalen = 50 adult male rats allocated to five groupsIntragastric administration20 mg/kg/day (low dose) and 40 mg/kg/day (high dose); a 40…Concurrent with injury induction: tannic acid given every morning and arsenic t…
Model: Arsenic trioxide-induced cardiotoxicity, produced by intraperitoneal injection of arsenic trioxide 5 mg/kg/day for 7 days
Both tannic acid doses preserved near-normal myocardial architecture, significantly lowered serum creatine kinase and lactate dehydrogenase, reduced myocardial reactive oxygen species and malondialdehyde, restored superoxide dismutase and catalase activity, and reduced cytochrome c, Smac, HtrA2, Ba…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
RatChemical/toxinSprague-DawleyMale20 and 40 mg/kgStarted 3 days before doxorubicin and continued after it, with doxorubicin inje…
Model: Acute cardiotoxicity induced by a single intraperitoneal injection of doxorubicin 10 mg/kg
Tannic acid pretreatment normalised serum lactate dehydrogenase, creatine kinase and creatine kinase-MB, raised antioxidant enzyme activity and lowered malondialdehyde, suppressed tumour necrosis factor alpha, interleukin 1 beta, endothelin 1 and NF-kappaB, and reduced apoptotic signalling.
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
