The Effect of Inflammation on the Healing Process of Acute Skin Wounds Under the Treatment of Wounds with Injections in Rats.
RatWoundWistarMalen = 28 animals per group at the outset in four groups, with 7 w…Injection into the inferolateral angles of the wound edges0.2 mL per wound of each solution: mesenchymal stem cells 1…On the day of wounding (day 0), immediately after wound modelling
Model: Standardised full-thickness square excisional skin wounds (11 mm sides, depth extending to the fascia, mean area 127.7 +/- 2.0 mm2) created bilaterally on the shaved back under chloral hydrate anaesthesia (300 mg/kg intraperitoneally) in non-sterile conditions
Stem cell injection reduced leukocyte infiltration of wound edges up to day 14, produced the thinnest scabs and the earliest transition from the exudative to the proliferative phase, with wound area already reduced by 9% at day 3 and by 88% at day 14 and complete epithelial coverage in 57% of wound…
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