THERAPY DOSSIER · th-27e548482f76

Human umbilical cord-derived mesenchymal stem cells; type I collagen (Collost 7%); deproteinised haemoderivative of calf blood (Actovegin)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 8

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02223897 ↗PHASE2/PHASE3unknown

Umbilical Cord MSC Transplantation for Ischemic-type Biliary Lesions After Liver Transplantation

Ischemic-type Biliary Lesions

Enrolment: 66 · Results not recorded

NCT06058078 ↗PHASE2recruiting

Safety, Tolerability, and Efficacy of RY_SW01 Cell Injection Therapy in Active Lupus Nephritis

Lupus Nephritis

Enrolment: 60 · Results not recorded

NCT03516006 ↗PHASE1/PHASE2unknown

Intra-arterial Injection of Umbilical Cord MSC in Primary Sclerosing Cholangitis

Primary Sclerosing Cholangitis

Enrolment: 20 · Results not recorded

NCT02947191 ↗PHASE1/PHASE2unknown

Collagen Membrane Combined With Human UC-MSC Transplantation in Nasal Septum Perforation

Chronic Nasal Septum Perforation

Enrolment: 12 · Results not recorded

NCT05794425 ↗PHASE1/PHASE2unknown

Umbilical Cord Blood Combined With UC-Derived MSC in Bone Marrow Failure Disorders

Bone Marrow Failure Disorders

Enrolment: 100 · Results not recorded

NCT06629909 ↗PHASE1not yet recruiting

Safety and Feasibility of Human Umbilical Cord MSC-Derived Secretome in Liver Cirrhosis

Liver Cirrhosis

Enrolment: 54 · Results not recorded

NCT06984497 ↗NAnot yet recruiting

Efficacy and Safety of Different Transplantation Routes of Human UC-MSC in End-stage Liver Disease

End-Stage Liver Diseases

Enrolment: 32 · Results not recorded

NCT06078059 ↗NAcompleted

Cultured Allogeneic MSCs in Knee Osteoarthritis

Osteoarthritis, Knee

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33154679 ↗2020Mixed findings

The Effect of Inflammation on the Healing Process of Acute Skin Wounds Under the Treatment of Wounds with Injections in Rats.

RatWoundWistarMalen = 28 animals per group at the outset in four groups, with 7 w…Injection into the inferolateral angles of the wound edges0.2 mL per wound of each solution: mesenchymal stem cells 1…On the day of wounding (day 0), immediately after wound modelling

Model: Standardised full-thickness square excisional skin wounds (11 mm sides, depth extending to the fascia, mean area 127.7 +/- 2.0 mm2) created bilaterally on the shaved back under chloral hydrate anaesthesia (300 mg/kg intraperitoneally) in non-sterile conditions

Stem cell injection reduced leukocyte infiltration of wound edges up to day 14, produced the thinnest scabs and the earliest transition from the exudative to the proliferative phase, with wound area already reduced by 9% at day 3 and by 88% at day 14 and complete epithelial coverage in 57% of wound…

Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.

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