Ethanol Intoxication Alleviates the Inflammatory Response of Remote Organs to Experimental Traumatic Brain Injury.
MouseTBIWeight-drop / impact-accelerationB6-SJL wild-typeMalen = Sham ethanol n=6; sham saline n=6; 3 h traumatic brain inju…Oral gavage5 g/kg as a 32% ethanol solution in saline, given at 20 mic…30 min before induction of traumatic brain injury, chosen to coincide with peak…
Model: Closed head blunt traumatic brain injury by weight drop (modified Shohami model); 333 g impactor dropped from 3 cm onto the centre of the right parietal bone, transferring approximately 0.098 J and about 32 N impact force, under sevoflurane anaesthesia
Ethanol intoxication reduced traumatic brain injury induced gene expression of HMGB1, IL-6 and MMP9 in liver and of HMGB1, IL-6, IL-1beta and TNF in lung, and reduced hepatic IL-6 protein at 3 h and histological HMGB1 at 6 h, while enhancing hepatic RAGE protein at 6 h. Hepatic IL-1beta and MMP9 ge…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.