Trial title not recorded
Adherence · HIV Risk Behaviors · Alcohol & Drug Use · Health Behaviors · Sexual Risk Behaviors
Enrolment: 60 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Adherence · HIV Risk Behaviors · Alcohol & Drug Use · Health Behaviors · Sexual Risk Behaviors
Enrolment: 60 · Results not recorded
Binge Drinking
Enrolment: 12 · Results not recorded
Diabetes
Enrolment: 60 · Results not recorded
Pain
Enrolment: 84 · Results not recorded
Alcohol Use Disorder (AUD)
Enrolment: 58 · Results not recorded
Scleroderma
Enrolment: 62 · Results not recorded
Alcohol Misuse
Enrolment: 9571 · Results not recorded
Stress · Breast Cancer · Telomere Length, Mean Leukocyte
Enrolment: 120 · Results not recorded
Alcohol Drinking · Coping Skills
Enrolment: 120 · Results not recorded
Anxiety
Enrolment: 450 · Results not recorded
8 studies reported at therapy level; 8 evidence entries itemised.
Model: Closed head blunt traumatic brain injury by weight drop (modified Shohami model); 333 g impactor dropped from 3 cm onto the centre of the right parietal bone, transferring approximately 0.098 J and about 32 N impact force, under sevoflurane anaesthesia
Ethanol intoxication reduced traumatic brain injury induced gene expression of HMGB1, IL-6 and MMP9 in liver and of HMGB1, IL-6, IL-1beta and TNF in lung, and reduced hepatic IL-6 protein at 3 h and histological HMGB1 at 6 h, while enhancing hepatic RAGE protein at 6 h. Hepatic IL-1beta and MMP9 ge…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Blunt chest (thoracic) trauma followed by 60 min haemorrhagic shock and resuscitation; sham animals underwent surgical procedures only
Ethanol significantly reduced trauma-induced IL-6, pulmonary polymorphonuclear leukocyte infiltration, lavage protein concentration, systemic leukocyte activation and monocyte inflammasome activation, but histological morphology changes after trauma were unaltered and neutrophil apoptosis was furth…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Closed weight-drop traumatic brain injury of moderate (2 cm falling height) or severe (3 cm falling height) severity
Ethanol given 30 min before moderate traumatic brain injury reduced neurological impairment, accelerated recovery and preserved neuronal numbers, with attenuated induction of a subset of immediate early genes, whereas post-injury administration and severe injury showed little or no benefit.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Closed blunt weight-drop traumatic brain injury, with and without traumatic intracerebral haemorrhage
Ethanol pretreatment produced faster and more complete neurological recovery after weight-drop TBI, with reduced leukocyte infiltration and microglial activation. Parenchymal GM-CSF, IL-6 and IL-3 fell and IL-13 and VEGF were transiently raised, with a delayed IL-6 peak and suppressed GM-CSF, IFN-g…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Blunt traumatic brain injury by weight-drop device under 2% isoflurane
Pre-injury ethanol reduced local and systemic proinflammatory cytokine responses but slowed neurological recovery and significantly increased post-traumatic apnoea time.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Closed head impact-acceleration traumatic brain injury using the Marmarou method
Ethanol given 60 minutes after traumatic brain injury significantly reduced brain water content and aquaporin mRNA and protein expression compared with untreated injury. Treated animals also showed significantly faster radial maze completion times and improved motor coordination.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Blunt weight-drop traumatic brain injury with simulated ethanol intoxication
Ethanol intoxication downregulated injury-induced IL-33, IL-1beta, IL-38, TNF-alpha and IL-19 and upregulated IL-13 and IL-12, reduced microglial activation and astrogliosis and preserved synaptic density and baseline neuronal activity at 7 days; STAT6 inhibition reversed these effects and negated…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Experimental traumatic brain injury after craniotomy
Caspase-3 activity rose after trauma and was lower in the trauma plus alcohol group, suggesting reduced apoptotic cell death.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.