Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia.
RatOtherIntranasal, compared with oral administrationGiven for prevention of hypoxia induced brain injury; exact timing relative to…
Model: Acute high-altitude hypobaric hypoxia induced brain injury produced in a hypobaric simulation chamber
Intranasal puerarin thermosensitive in situ hydrogel improved spatial memory and spontaneous exploratory behaviour, lowered malondialdehyde and glutathione in the peripheral circulation, reduced cerebral histological lesions and hypoxia-inducible factor-1alpha expression. It was absorbed rapidly (T…
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