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PRECLINICAL PUBLICATION · 2020

Effect of Durotomy versus Myelotomy on Tissue Sparing and Functional Outcome after Spinal Cord Injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 33121382 ↗2020Mixed findings

Effect of Durotomy versus Myelotomy on Tissue Sparing and Functional Outcome after Spinal Cord Injury.

RatSpinal cord injuryUnspecifiedLong-EvansFemaleSurgicalAcutely after traumatic spinal cord injury

Model: Acute traumatic thoracic spinal cord injury in a rodent model, causing local tissue oedema and elevated intraspinal pressure

Traumatic spinal cord injury raised intraspinal pressure to 7.4 plus or minus 0.3 mmHg versus a physiological 1.7 plus or minus 0.4 mmHg, and both decompression strategies mitigated this. At 10 weeks, durotomy plus myelotomy increased tissue sparing by 13.7% relative to durotomy alone and by 25.9%…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.