THERAPY DOSSIER · th-fdf29a4424ee

Durotomy alone versus durotomy plus myelotomy (surgical decompression)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06243211 ↗Injury indicationNArecruiting

Minimizing Secondary Injury in Patients With SCI Using Expansive Duroplasty

Spinal Cord Injuries · Acute Traumatic Spinal Cord Injury

Enrolment: 10 · Results not recorded

NCT02927782 ↗NAunknown

Flat Bed Rest vs. Immediate Mobilisation After Incidental Durotomy During Lumbar Spinal Surgery

Cerebrospinal Fluid Leak

Enrolment: 60 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33121382 ↗2020Mixed findings

Effect of Durotomy versus Myelotomy on Tissue Sparing and Functional Outcome after Spinal Cord Injury.

RatSpinal cord injuryUnspecifiedLong-EvansFemaleSurgicalAcutely after traumatic spinal cord injury

Model: Acute traumatic thoracic spinal cord injury in a rodent model, causing local tissue oedema and elevated intraspinal pressure

Traumatic spinal cord injury raised intraspinal pressure to 7.4 plus or minus 0.3 mmHg versus a physiological 1.7 plus or minus 0.4 mmHg, and both decompression strategies mitigated this. At 10 weeks, durotomy plus myelotomy increased tissue sparing by 13.7% relative to durotomy alone and by 25.9%…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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