Radioprotective effects of lipid A, liposomes, and liposomes containing lipid A in mice.
MouseRadiationICRFemaleProphylactic pretreatment before irradiation
Model: Lethal whole-body gamma irradiation (acute radiation syndrome)
Spleen colony formation was increased by lipid A alone and more strongly by liposomal lipid A. Where 100% of untreated or saline-treated mice died of acute radiation syndrome by 20 days, more than 90% of mice pretreated with liposomal lipid A were alive at 30 days. Liposomes alone gave mild radiopr…
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