Phase IIa Study of the Contribution of MPL to Tyrosine-Adsorbed Birch/Hazel/Alder Pollen Allergoid (Tree MATA MPL)
Type I Hypersensitivity
Enrolment: 40 · Results not recorded
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Other · No ChEMBL match for lipid A or liposome carriers. Human exposure exists only via the detoxified derivative monophosphoryl lipid A (MPL) used as a vaccine adjuvant; the listed trials are MPL-adjuvanted vaccine and allergoid studies, not the free lipid A/liposome preparation studied preclinically. Flagged as an indirect trial match.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Type I Hypersensitivity
Enrolment: 40 · Results not recorded
Type I Hypersensitivity
Enrolment: 41 · Results not recorded
Norovirus Prevention
Enrolment: 454 · Results not recorded
Hookworm Infection
Enrolment: 40 · Results not recorded
Gastroenteritis
Enrolment: 102 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Lethal whole-body gamma irradiation (acute radiation syndrome)
Spleen colony formation was increased by lipid A alone and more strongly by liposomal lipid A. Where 100% of untreated or saline-treated mice died of acute radiation syndrome by 20 days, more than 90% of mice pretreated with liposomal lipid A were alive at 30 days. Liposomes alone gave mild radiopr…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.