Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia-reperfusion.
MixedIschaemia-reperfusionOther / unspecifiedC57BL/6MalePretreatment before ischaemia
Model: Lung ischaemia-reperfusion injury in vivo; hypoxia/reoxygenation in lung epithelial cells in vitro
Liproxstatin-1 pretreatment and ACSL4 inhibition with rosiglitazone reduced lipid peroxidation, raised glutathione and GPX4 and attenuated ferroptotic lung ischaemia-reperfusion injury.
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