Gene Regulation by Thiazolidinediones
Inflammatory Bowel Disease
Enrolment: 12 · Results not recorded
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Drug · Peroxisome proliferator-activated receptor gamma agonist
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Inflammatory Bowel Disease
Enrolment: 12 · Results not recorded
NASH (Non-alcoholic Steato-hepatitis)
Enrolment: 26 · Results not recorded
Coronary Artery Disease
Enrolment: 200 · Results not recorded
Neuropathy, Diabetic
Enrolment: 36 · Results not recorded
Alzheimer's Disease
Enrolment: 1468 · Results not recorded
Atherosclerosis
Enrolment: 672 · Results not recorded
Diabetes Mellitus, Type 2
Enrolment: 227 · Results not recorded
Sarcoma
Enrolment: 32 · Results not recorded
Diabetes Mellitus, Type II · Insulin Resistance
Enrolment: 70 · Results not recorded
Ulcerative Colitis
Enrolment: 20 · Results not recorded
Asthma
Enrolment: 26 · Results not recorded
Diabetes Mellitus, Type II
Enrolment: 78 · Results not recorded
Healthy Subjects
Enrolment: 24 · Results not recorded
HIV Infections · Lipodystrophy · Hyperinsulinemia
Enrolment: 105 · Results not recorded
9 studies reported at therapy level; 9 evidence entries itemised.
Model: Surgical skin incision (postincisional pain model) in type 2 diabetic db/db mice, with outcomes followed for 7 days after incision
Rosiglitazone plus resolvin D1 alleviated mechanical hyperalgesia in db/db mice whereas rosiglitazone alone did not (day 4: 0.506 plus or minus 0.106 versus 0.068 plus or minus 0.12; day 7: 0.529 plus or minus 0.184 versus 0.153 plus or minus 0.183). The combination markedly reduced local neutrophi…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Lung ischaemia-reperfusion injury in vivo; hypoxia/reoxygenation in lung epithelial cells in vitro
Liproxstatin-1 pretreatment and ACSL4 inhibition with rosiglitazone reduced lipid peroxidation, raised glutathione and GPX4 and attenuated ferroptotic lung ischaemia-reperfusion injury.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Abdominal irradiation (9 Gy caesium gamma, 2.5 Gy/min) inducing acute small intestinal injury
Rosiglitazone improved villus height and crypt counts and reduced inflammatory cell infiltration compared with irradiation alone, and lowered serum IL-1beta (15.71 versus 41.56 pg/ml) and TNF-alpha (32.43 versus 47.61 pg/ml) along with reduced caspase-1 and NLRP3 expression. Co-administration of mo…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Six full-thickness excisional wounds, 5 mm in diameter and 3 to 4 mm apart, made on the back by excising skin and underlying panniculus carnosus under ketamine (80 mg/kg) and isoflurane anaesthesia
Oral rosiglitazone markedly improved the disturbed wound conditions in obese mice, giving complete re-epithelialisation and a collagen-enriched neo-dermis by day 13, a marked reduction in wound CXCL2 and cyclooxygenase-2 mRNA and protein, more regular subcutaneous adipocyte morphology, lower fastin…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Controlled cortical impact over the left parietal cortex through a 5 mm craniotomy, 2.5 mm rounded metal tip angled 22.5 degrees from vertical, velocity 4 m/s, deformation depth 2 mm below the dura
A single intraperitoneal dose of rosiglitazone given immediately after controlled cortical impact improved motor function recovery at days 1, 4 and 7, reduced caspase 3, Beclin-1 and LC3-II/LC3-I expression, increased Bcl-2, and lowered TNF-alpha and IL-6 in the cortex. No significant change was se…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Hyperlipidaemic pancreatitis with associated acute renal injury in rats; induction method not stated in the available text
Rosiglitazone inhibited activation of the NF-kappaB and MAPK p38 signalling pathways, relieved the inflammatory response and inhibited cell apoptosis, thereby attenuating renal injury caused by hyperlipidaemic pancreatitis. The authors suggest rosiglitazone may be a promising drug for treating rena…
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.
Model: Global cerebral ischaemia with reperfusion
A single injection of rosiglitazone immediately after global cerebral ischaemia reduced infarct volume and brain oedema, increased neuronal survival and functional recovery, and lowered inflammatory cytokines and autophagy-associated proteins in hippocampus.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Surgical incision producing postincisional pain
Local rosiglitazone significantly reduced heat and mechanical hypersensitivity and paw swelling, decreased M1 and increased M2 macrophage numbers at 24 h, raised M2-associated gene expression and lowered M1-associated gene expression. Transplantation of rosiglitazone-treated peritoneal macrophages…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Spinal cord contusion injury with laminectomy
Rosiglitazone increased nerve growth factor expression more than methylprednisolone and improved early motor recovery after spinal cord injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.