Non-invasive neuromodulation using rTMS and the electromagnetic-perceptive gene (EPG) facilitates plasticity after nerve injury.
RatOtherSprague-Dawley19 male and 16 femalen = 35 rats total, 29 denervated; n = 5-6 per group; fMRI n = 5…Non-invasive transcranial magnetic stimulation; stereotaxic intracortical AAV injection with an electromagnet over S1rTMS: 10 Hz in 4 s cycles with 26 s intervals, 7 cycles, 28…rTMS acute arm from 48 h after denervation; rTMS delayed arm from 3 weeks after…
Model: Right forepaw denervation with radial, median and ulnar nerves cut and a 5 mm gap made in each
Both acute and delayed rTMS and EPG magnetic neuromodulation improved motor and exploratory behaviour and increased S1 fMRI activation and CaMKII expression, with only marginal effects on self-grooming.
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