Evidence & regulatory context
- Mechanism
- Physical/gene-therapy combination; no ChEMBL entity. The rTMS component is extensively trialled in humans (1257 ClinicalTrials.gov records for the keyword; 9 relevance-filtered here, prioritising trauma, brain injury and neurological indications). The AAV2-delivered electromagnetic-perceptive gene (EPG) component has no human trial and remains preclinical.
- Target
- Not recorded
- Injury models
- Other
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 9
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
ADEPT: Adaptive Trial for Treatment of Depressive Symptoms Associated With Concussion Using Repetitive Transcranial Magnetic Stimulation Protocols
Depressive Symptoms · Mild Traumatic Brain Injury · Concussion
Enrolment: 198 · Results not recorded
Intermittent Theta Burst Versus 10 Hz Repetitive Transcranial Magnetic Stimulation for Neuropathic Pain in Spinal Cord Injury
Neuropathic Pain · Spinal Cord Injury
Enrolment: 26 · Results not recorded
10 Hz Repetitive Transcranial Magnetic Stimulation Versus Intermittent Theta Burst Stimulation for Treatment-Resistant Depression
Major Depressive Disorder
Enrolment: 20 · Results not recorded
Effectiveness of Speech Therapy and Repetitive Transcranial Magnetic Stimulation in Patients With Post-stroke Anomic Aphasia
Aphasia · Stroke
Enrolment: 25 · Results not recorded
Efficacy and Mechanism of SMA+M1 Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in Parkinson Disease
Parkinson Disease
Enrolment: 64 · Results not recorded
Accelerated rTMS Targeting Motor Cortex on Motor and Cognitive Function in Parkinson's Disease: Prospective Pilot Study
Parkinson Disease
Enrolment: 40 · Results not recorded
Cortical rTMS as a Treatment for Depression
Major Depressive Disorder
Enrolment: 50 · Results not recorded
Accelerated Sequential Bilateral Theta Burst Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Late-life Depression
Treatment Resistant Depression
Enrolment: 30 · Results not recorded
Usefulness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Chronic Tinnitus
Tinnitus
Enrolment: 80 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatOtherSprague-Dawley19 male and 16 femalen = 35 rats total, 29 denervated; n = 5-6 per group; fMRI n = 5…Non-invasive transcranial magnetic stimulation; stereotaxic intracortical AAV injection with an electromagnet over S1rTMS: 10 Hz in 4 s cycles with 26 s intervals, 7 cycles, 28…rTMS acute arm from 48 h after denervation; rTMS delayed arm from 3 weeks after…
Model: Right forepaw denervation with radial, median and ulnar nerves cut and a 5 mm gap made in each
Both acute and delayed rTMS and EPG magnetic neuromodulation improved motor and exploratory behaviour and increased S1 fMRI activation and CaMKII expression, with only marginal effects on self-grooming.
Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
