Wild Bitter Melon Exerts Anti-Inflammatory Effects by Upregulating Injury-Attenuated CISD2 Expression following Spinal Cord Injury.
MouseSpinal cord injuryHemisection / partialC57BL/6JNarl (wild type)n = n = 6 per group (3 per time point at 8 and 24 h); three gro…Intraperitoneal500 mg/kg body weightImmediately after spinal cord injury
Model: Spinal cord hemisection at the ninth to tenth thoracic vertebra after laminectomy, using a wire knife extended 1.5 mm and lifted 4.0 mm
Wild bitter melon mitigated the injury-induced downregulation of CISD2, PPAR and IkB and reduced upregulation of GFAP, IL-1 and IL-6 in the injured spinal cord, with GFAP and CISD2 effects significant at 24 h but not 8 h. In vitro, 1 microgram per mL extract or 0.28 micrograms per mL alpha-eleostea…
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