THERAPY DOSSIER · th-2168b94bbde3

Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) water then ethanol extract; alpha-eleostearic acid identified as bioactive component

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00823953 ↗PHASE2withdrawn

The Effect of Momordica Charantia on Glycemic Control and Insulin Resistance in Type 2 Diabetes

Type 2 Diabetes

Enrolment: 0 · Results not recorded

NCT06036030 ↗PHASE2completed

Combination Momordica Charantia Extract and Primaquine Against Uncomplicated P. falciparum and P. vivax Malaria

Malaria, Falciparum · Malaria, Vivax

Enrolment: 50 · Results not recorded

NCT04916379 ↗NAunknown

Effect of Momordica Charantia Administration on Anthropometric Indicators in Patients With Obesity

Obesity

Enrolment: 24 · Results not recorded

NCT07504029 ↗NArecruiting

Human Clinical Trial Evaluating the Blood Glucose-Regulating Effects of Momordica Charantia Peptides

People With Prediabetic

Enrolment: 12 · Results not recorded

NCT04090788 ↗NAcompleted

The Effect of Momordica Charantia Supplementation on Blood Glucose Levels

Glucose Intolerance

Enrolment: 30 · Results not recorded

NCT03151837 ↗NAcompleted

Hypoglycemic Efficacy of Greenyn Momordica Charantia Extracts in Diabetic Subjects

Diabetes Mellitus, Type 2

Enrolment: 40 · Results not recorded

NCT04268212 ↗NAcompleted

Effects of Bitter Melon Intake and Moderate-Intensity Physical Activity on Postprandial Glucose Responses in Type 2 Diabetic Patients

Type 2 Diabetes

Enrolment: 8 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33062068 ↗2020Reported benefit

Wild Bitter Melon Exerts Anti-Inflammatory Effects by Upregulating Injury-Attenuated CISD2 Expression following Spinal Cord Injury.

MouseSpinal cord injuryHemisection / partialC57BL/6JNarl (wild type)n = n = 6 per group (3 per time point at 8 and 24 h); three gro…Intraperitoneal500 mg/kg body weightImmediately after spinal cord injury

Model: Spinal cord hemisection at the ninth to tenth thoracic vertebra after laminectomy, using a wire knife extended 1.5 mm and lifted 4.0 mm

Wild bitter melon mitigated the injury-induced downregulation of CISD2, PPAR and IkB and reduced upregulation of GFAP, IL-1 and IL-6 in the injured spinal cord, with GFAP and CISD2 effects significant at 24 h but not 8 h. In vitro, 1 microgram per mL extract or 0.28 micrograms per mL alpha-eleostea…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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