A single dose of estrogen during hemorrhagic shock protects against Kidney Injury whereas estrogen restoration in ovariectomized mice is ineffective.
MouseHaemorrhage/shockControlledC57BL/6JFemaleIntravenous bolus at resuscitation; subcutaneous pellet for chronic restorationSingle bolus 25 microgram per mouse (reported as 1 mg/kg) i…Bolus at resuscitation, end of the 2 h shock period; chronic pellets implanted…
Model: Pressure-controlled resuscitated haemorrhagic shock: femoral artery blood withdrawal to mean arterial pressure 35 mmHg, maintained 2 h, then reinfusion of shed blood plus equal volume Ringer's lactate
A single high-dose intravenous oestradiol bolus at resuscitation in intact female mice reduced the day 1 rise in renal KIM-1 by about two thirds, lowered activated caspases 8, 1 and 11, reduced TLR4 and IL-1beta, normalised GRP78 and CHOP, and prevented about one third of day 21 collagen III fibros…
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