Double blind placebo controlled trial of Zesteem (estradiol) in accelerating the healing of split thickness skin graft donor sites
Burn · Trauma · Varicose Ulcer
Enrolment: 148 · Results not recorded
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Hormone · Estrogen receptor alpha agonist (AGONIST; direct interaction)
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Burn · Trauma · Varicose Ulcer
Enrolment: 148 · Results not recorded
Traumatic Brain Injury
Enrolment: 50 · Results not recorded
PTSD · Trauma
Enrolment: 127 · Results not recorded
Endometrium
Enrolment: 100 · Results not recorded
Postmenopausal Symptoms
Enrolment: 44 · Results not recorded
Other Disorders of Bone Development and Growth
Enrolment: 6 · Results not recorded
Turner Syndrome · Hypogonadism · Premature Ovarian Failure
Enrolment: 41 · Results not recorded
Vasomotor Symptoms
Enrolment: 204 · Results not recorded
Healthy Symptomatic Menopausal Women
Enrolment: 99 · Results not recorded
Atrophic Vaginitis
Enrolment: 63 · Results not recorded
Contraception · Female Contraception
Enrolment: 1494 · Results not recorded
Hot Flashes
Enrolment: 454 · Results not recorded
Contraception
Enrolment: 2016 · Results not recorded
Premature Ovarian Insufficiency
Enrolment: 185 · Results not recorded
Endometriosis
Enrolment: 145 · Results not recorded
Type 1 Diabetes
Enrolment: 0 · Results not recorded
Tuberculosis
Enrolment: 20 · Results not recorded
Menstruation Disturbances
Enrolment: 9 · Results not recorded
Postmenopausal Vaginal Atrophy
Enrolment: 500000 · Results not recorded
Embryo Implantation · ART
Enrolment: 356 · Results not recorded
20 studies reported at therapy level; 29 evidence entries itemised.
Model: Acute spinal cord injury at the thoracic level; the specific injury procedure is not stated in the abstract
Estrogen treatment significantly increased vessel number, vessel volume fraction and vessel connectivity (p less than 0.05), reduced the injury-induced lesion area and improved locomotor functional recovery.
Extraction: extract · Supplied extraction confidence: 0.45. Machine-extracted fields require source verification.
Model: Acute spinal cord injury
Estrogen shifted the Bcl-2 expression peak from day 3 to day 8, reduced apoptosis of neurons and glial cells, and gave higher Gale scores and inclined plate maintenance rates than injury alone at 2 weeks. Animals were assessed at 1, 3, 5, 8, 14 and 21 days after injury.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: eccentric contraction injury of the left plantarflexors by percutaneous tibial nerve stimulation (150 Hz, 4 V, 0.2 ms) with the ankle dorsiflexed through 26 degrees, 3 bouts of 150 trials
Short-term estrogen or progesterone did not change body weight or the number or area percentage of 7/4-positive leukocytes in injured muscle. The estrogen-only group showed a 2 to 3-fold greater mean 7/4 antigen area, suggesting altered leukocyte phenotype.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: left lung transplantation ischaemia-reperfusion (6 h ischaemia)
Estradiol worsened injury and caused severe oedema, whereas desferrioxamine and melatonin had no effect on injury or rejection.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Moderately severe contusion spinal cord injury at T10 (40 g.cm, 5 g weight dropped from 8 cm) after laminectomy; sham animals received laminectomy only
Low dose 17beta-oestradiol reduced GFAP reactivity, calpain and caspase-3 expression and activity, shifted the Bax:Bcl2 ratio towards survival and upregulated ERalpha, ERbeta and VEGF at 48 h. Neuronal TUNEL positivity was attenuated at 5 and 10 ug/kg, with 10 ug/kg as effective as 100 ug/kg.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Seawater aspiration-induced acute lung injury
17beta-estradiol downregulated aquaporins 1 and 5 and attenuated seawater aspiration-induced acute lung injury and oedema.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Acute spinal cord injury
Low-dose 17beta-estradiol reduced microglial activation and neuronal apoptosis after acute spinal cord injury in rats regardless of dose, route or timing.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Doxorubicin-induced cardiotoxicity, single doxorubicin 10 mg/kg by lateral tail vein injection 24 h after subcutaneous implantation of 8.5 x 10^6 SST-2 cells into the right mammary fat pad
Exogenous 17beta-estradiol suppressed doxorubicin-induced cardiotoxicity in ovariectomised SHRs, while progesterone-implanted animals were only partly resistant and the estradiol plus progesterone combination gave no cardioprotection. Estrous stage at treatment altered damage, with proestrus-treate…
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Lateral fluid percussion traumatic brain injury
A single intravenous bolus of 17beta-estradiol or G-1 given 1 h after lateral fluid percussion injury increased neuronal survival in the ipsilateral CA2/3 hippocampus and reduced neuronal degeneration, apoptotic cell death and astrogliosis at 24 h. Effects were dose-dependent for 17beta-estradiol.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: 40 per cent total body surface area full-thickness scald burn by immersion of the back and flank in water at 100 degrees Celsius for 10 seconds, with sham animals immersed in room-temperature water, followed by Parkland formula resuscitation of 4 mL/kg per percent burn of lactated Ringer solution intraperitoneally, half immediately and half over 8 h
A single subcutaneous dose of 17beta-estradiol given 15 min after a 40 per cent total body surface area scald burn spared body mass during the first two weeks and improved the recovery phase, but fasting glucose and insulin did not differ from vehicle.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
Model: Neonatal hypoxic-ischaemic brain injury by ligation of the left common carotid artery followed by 80 minutes of hypoxia in 8 per cent oxygen
Microscopic brain damage score was significantly lower with 17beta-estradiol (1.5 plus or minus 0.7 versus 2.8 plus or minus 0.8, p < 0.05) and affected hemisphere volumes were preserved. Apoptotic cell numbers were equal between hemispheres in the estradiol group, whereas controls had significantl…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Isolated perfused ventilated lung injured by paraquat oxidant stress, N-methyl-D-aspartate excitotoxicity or acute alveolar anoxia
Estradiol significantly attenuated lung injury in all three models, with paraquat producing the most severe injury, and rapidly stimulated vasoactive intestinal peptide mRNA expression in rat lung, suggesting partial mediation of the protection by VIP.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute spinal cord injury, assessed in a per-acute model at 6 h after injury
Spinal cord tissue estrogen concentrations were double plasma concentrations, confirming focal release. Estrogen rapidly and significantly reduced IL-6, GRO-KC, MCP-1 and S100beta in one or all compartments, and modulated additional targets including leptin, MIP-1alpha, IL-4, IL-2, IL-10, IFN-gamma…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Cerulein-induced acute pancreatitis with associated lung injury
Estradiol attenuated pancreatitis-associated lung injury via the Akt pathway, an effect abolished by Wortmannin.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Neonatal ionizing gamma radiation exposure of developing cerebellum
Chronic 17-beta-estradiol partially protected against radiation-induced cerebellar disorganisation and motor abnormalities, possibly via PKC and NOS.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Third degree scald burn covering 40% of total body surface area
Post-burn 17-beta-estradiol reduced mitochondrial oxidative damage and release of mitochondrial danger associated molecular patterns, lowered myocardial apoptosis and inflammatory signalling, reduced troponin I and improved cardiac morphology and contractility 24 hours after burn
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Acute cutaneous wound in the context of post-menopausal delayed healing; in vitro 3T3-L1 cell culture
The abstract reports characterisation of the estradiol-loaded polyurethane-dextran nanofibre mats together with cell growth and proliferation analysis to assess suitability as a wound dressing, without stating quantitative in vivo healing outcomes.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Eccentric contraction injury of the left plantar flexor muscles in ovariectomised mice using a servomotor, three bouts of 150 trials with electrically stimulated isometric contraction followed by forced stretch
At 48 h after eccentric contraction injury, oestrogen-positive mice had more 7/4-positive and Ly6C/G-positive myofibres, a greater 7/4 area percentage and more 7/4-positive connective tissue cells than oestrogen-negative mice. Time to fatigue did not differ between groups, indicating comparable ini…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Pressure-controlled resuscitated haemorrhagic shock: femoral artery blood withdrawal to mean arterial pressure 35 mmHg, maintained 2 h, then reinfusion of shed blood plus equal volume Ringer's lactate
A single high-dose intravenous oestradiol bolus at resuscitation in intact female mice reduced the day 1 rise in renal KIM-1 by about two thirds, lowered activated caspases 8, 1 and 11, reduced TLR4 and IL-1beta, normalised GRP78 and CHOP, and prevented about one third of day 21 collagen III fibros…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Spinal cord ischaemia-reperfusion: transient endovascular occlusion of the proximal descending thoracic aorta for 12 minutes
Neither oestradiol nor progesterone given 30 minutes before occlusion prevented or attenuated spinal cord ischaemic injury; functional scores, viable neuron counts and immunostaining did not differ between groups
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.