Acute injection of a DHA triglyceride emulsion after hypoxic-ischemic brain injury in mice increases both DHA and EPA levels in blood and brain.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6Jn = Biodistribution 6 to 7 animals per group per time point; GC…Intraperitoneal0.375 g tri-DHA per kg body weight per injectionImmediately after the end of hypoxia, at the start of reperfusion
Model: Unilateral neonatal cerebral hypoxia-ischaemia: permanent right common carotid artery ligation followed after 1.5 h by 15 min hypoxia (8 per cent oxygen) at 37 degrees C; shams had carotid exposure only
Brain uptake of intact emulsion particles was the lowest of all organs assayed (under 0.4 per cent of recovered dose), with liver highest. Tri-DHA raised DHA in plasma lysophosphatidylcholine, non-esterified fatty acid and triglyceride pools, and raised EPA in non-esterified fatty acid and triglyce…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.