Omega-3 Supplementation to Increase HDL-c Levels in Those With Tetraplegia
Spinal Cord Injury · Tetraplegia · Low HDL-c · High LDL-c
Enrolment: 21 · Results not recorded
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Nutraceutical
5 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Spinal Cord Injury · Tetraplegia · Low HDL-c · High LDL-c
Enrolment: 21 · Results not recorded
Mild Traumatic Brain Injury
Enrolment: 44 · Results not recorded
Chronic Pain Following Thermal Burn Injury
Enrolment: 24 · Results not recorded
Concussion · Mild Traumatic Brain Injury
Enrolment: 40 · Results not recorded
Concussion, Mild
Enrolment: 140 · Results not recorded
Severe Hypertriglyceridemia
Enrolment: 54 · Results not recorded
Renal Failure, Chronic
Enrolment: 60 · Results not recorded
Retinopathy of Prematurity
Enrolment: 48 · Results not recorded
Breast Cancer
Enrolment: 24 · Results not recorded
Ischemic Stroke · Transient Ischemic Attack
Enrolment: 60 · Results not recorded
Muscle Damage
Enrolment: 2 · Results not recorded
Prostate Cancer
Enrolment: 37 · Results not recorded
Lactation
Enrolment: 24 · Results not recorded
Stroke
Enrolment: 290 · Results not recorded
Pressure Sores · Intensive Care
Enrolment: 40 · Results not recorded
Infant, Premature, Diseases
Enrolment: 80 · Results not recorded
Ophthalmological Disorder
Enrolment: 210 · Results not recorded
12 studies reported at therapy level; 12 evidence entries itemised.
Model: Sub-acute manganese intoxication (manganism) induced with manganese at 30 mg/kg
Manganese intoxication reduced distance travelled by 46 percent, mean speed by 36 percent and rotarod performance to 42 percent, and lowered the weights test score, alongside disrupted tyrosine hydroxylase immunoreactivity in the nigrostriatal pathway. Pretreatment with docosahexaenoic acid maintai…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Controlled cortical impact traumatic brain injury
A single intravenous bolus of docosahexaenoic acid at 30 min post-injury significantly reduced neurological deficit for up to 28 days, raised pro-resolving mediators in the injured hemisphere, reduced lesion size, microglial and astrocytic reaction, oxidation and beta-amyloid precursor protein accu…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Controlled cortical impact traumatic brain injury in the developing brain
Docosahexaenoic acid lowered oxidative stress at day 1 and pro-inflammatory microglial activation at day 3, blunted interferon regulatory factor and pro-inflammatory gene induction in microglia-enriched populations, and improved novel object recognition at day 14.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Severe contusion spinal cord injury at thoracic level T10 without laminectomy, delivered with a stereotaxic frame and computer-controlled PinPoint precision impactor (tip #4, velocity 3 m/s, depth 5 mm, dwell time 800 ms)
DHA restored hindlimb locomotor function and the tail-flick reflex in mice that were otherwise permanently paraplegic, reduced gliosis, cavitation and microglial activation, lowered caspase-3, p75NTR and pJNK, and increased regenerated area at 60 days.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Spinal cord contusion injury in rats and mice, with parallel rat primary spinal microglia, BV2 cell and monocyte-derived macrophage cultures
Acute DHA at 500 nmol/kg conferred neuroprotection and improved locomotor recovery after contusion spinal cord injury, and reduced myelin phagocytosis by microglia at 7 days in parallel with increased miR-124. A miR-124 inhibitor reversed the reduction in phagocytosis in vivo and in BV2 cells. DHA…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Transient middle cerebral artery occlusion for 1 hour followed by reperfusion
Docosahexaenoic acid given after stroke reduced infarct volume and neurological deficits at 3 days, inhibited immune cell infiltration, promoted M2 macrophage polarisation centrally and in the circulation, and lowered blood pro-inflammatory factors. Macrophage depletion abolished the neuroprotectio…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Rat cervical hemisection spinal cord injury and mouse pyramidotomy
A single acute intravenous bolus of docosahexaenoic acid induced robust sprouting of uninjured corticospinal and serotonergic fibres, increased synaptophysin and contacts with V2a interneurons and motor neurons, upregulated miR-21 and phosphorylated AKT with downregulation of PTEN, and improved fun…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: T12 compression spinal cord injury after laminectomy
DHA reduced epicentre neutrophils and plasma C-reactive protein, EPA did not, and neither fatty acid normalised the acute cytokine or hepatic inflammatory response.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute contusive spinal cord injury in adult rats, with outcomes targeted at cellular and molecular events during the first week after injury
Docosahexaenoic acid pretreatment reduced acute functional deficits, with significantly improved Basso-Beattie-Bresnahan scores and detection of transcranial magnetic motor evoked potentials, and at 7 days post-injury significantly increased white matter sparing, axonal preservation and survival of…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Cervical lateral hemisection spinal cord injury
A single bolus of DHA combined with task-specific rehabilitation produced greater functional improvement than either treatment alone, with corresponding increases in corticospinal and serotonergic sprouting and in synaptophysin and Bassoon expression.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Controlled cortical impact (CCI) in the immature rat pup, with sham surgery controls
DHA did not adversely affect survival or weight gain; it acutely decreased oxidative stress and increased anti-inflammatory interleukin 10 in CCI brains, improved Morris water maze performance and lesion volume late after injury, and at post-injury day 12 decreased T2-imaging measures of cerebral o…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Unilateral neonatal cerebral hypoxia-ischaemia: permanent right common carotid artery ligation followed after 1.5 h by 15 min hypoxia (8 per cent oxygen) at 37 degrees C; shams had carotid exposure only
Brain uptake of intact emulsion particles was the lowest of all organs assayed (under 0.4 per cent of recovered dose), with liver highest. Tri-DHA raised DHA in plasma lysophosphatidylcholine, non-esterified fatty acid and triglyceride pools, and raised EPA in non-esterified fatty acid and triglyce…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.