Hyperbaric Oxygen Treatment Following Mid-Cervical Spinal Cord Injury Preserves Diaphragm Muscle Function.
RatSpinal cord injuryContusionSprague-DawleyMalen = n = 12 per group across 3 groups (36 rats)Inhalational, whole-body hyperbaric chamber100 per cent oxygen at 3 atmospheres absolute, 1 h per expo…Acute phase after injury; Methods state treatment began on the day of injury wh…
Model: Lateral cervical spinal cord contusion at C3/C4 after laminectomy using an Infinite Horizon pneumatic impactor under isoflurane anaesthesia
Cervical contusion reduced diaphragm specific force across all stimulation frequencies and caused atrophy of type I and type IIb/x fibres, with reduced mitochondrial respiratory control ratio and raised hydrogen peroxide emission. Ten days of hyperbaric oxygen fully preserved submaximal force at 15…
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