Hyperbaric Oxygenation (HBO) in Traumatic Spinal Cord Injury (EOS) Pilot Study
Traumatic Injury of the Spinal Cord
Enrolment: 11 · Results not recorded
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Procedure
6 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Traumatic Injury of the Spinal Cord
Enrolment: 11 · Results not recorded
TBI Traumatic Brain Injury · PTSD · Post Concussive Syndrome
Enrolment: 54 · Results not recorded
Wound
Enrolment: 50 · Results not recorded
Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias · Carbon Monoxide Poisoning · Decompression Sickness · Acute Thermal Burn Injury
Enrolment: 5000 · Results not recorded
Healthy Adults Without Brain Injury
Enrolment: 83 · Results not recorded
Traumatic Wounds · Diabetic Foot · Pressure Ulcer · Chronic Ulcer
Enrolment: 300000 · Results not recorded
Hyperbaric Oxygen Therapy · Mild Cognitive Impairment
Enrolment: 30 · Results not recorded
Carbon Monoxide Poisoning
Enrolment: 66 · Results not recorded
Decompression Sickness
Enrolment: 40 · Results not recorded
Ankle Sprain
Enrolment: 40 · Results not recorded
6 studies reported at therapy level; 6 evidence entries itemised.
Model: Lateral cervical spinal cord contusion at C3/C4 after laminectomy using an Infinite Horizon pneumatic impactor under isoflurane anaesthesia
Cervical contusion reduced diaphragm specific force across all stimulation frequencies and caused atrophy of type I and type IIb/x fibres, with reduced mitochondrial respiratory control ratio and raised hydrogen peroxide emission. Ten days of hyperbaric oxygen fully preserved submaximal force at 15…
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Model: Thoracic laminectomy followed by MASCIS weight-drop impactor from 12.5 mm (mild) or 25 mm (moderate) height
All animals receiving hyperbaric therapy showed significant improvement in motor function and histology compared with controls, with earlier motor recovery and smaller histological injury when therapy was started sooner and given for 7 days.
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Model: Traumatic brain injury, specific impact method not stated in abstract
Hyperbaric oxygen improved running speed, reduced local and systemic TNF-alpha, neuronal damage score and neuronal apoptosis, lowered TGIF and increased TGF-beta1 expression 72 h after injury.
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Model: Fluid percussion traumatic brain injury
Hyperbaric oxygen at either 1 or 8 h after injury improved inclined plane performance and reduced infarction, microglial activation, TNF-alpha expression and neuronal apoptosis.
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Model: Traumatic brain injury
Hyperbaric oxygen significantly reduced motor and cognitive dysfunction, cerebral infarction and apoptosis, inflammation, neuronal loss and gliosis, while stimulating angiogenesis, neurogenesis and interleukin-10 overproduction at 4 days after injury.
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Model: acute thoracic spinal cord injury induced by extradural aneurysm clip application at the T9-T11 level
Hyperbaric oxygen reduced nitric oxide synthase and nitric oxide activity in injured cord tissue, with reductions in superoxide dismutase and glutathione peroxidase in the treated groups, and improved BBB locomotor scores in the postoperative and combined treatment groups.
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