The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice.
MouseChemical/toxinBALB/cFemalen = 20 mice across 4 groups for the 2 mg/kg weight-change exper…Oral1 g/kg or 2 g/kgPretreatment, 30 minutes before cantharidin
Model: Acute cantharidin-induced cardiotoxicity, cantharidin in DMSO given intraperitoneally at 2 mg/kg (weight-loss experiment) or 3 mg/kg (survival, ECG, biomarker, histology and oxidative stress experiments)
L-glutamine pretreatment reduced cantharidin-induced weight loss and mortality, lowered the rise in cardiac mass index, attenuated ST segment elevation, significantly decreased serum CK, CK-MB, AST and LDH, reduced myocardial inflammatory infiltrate and interstitial hyperaemia, altered SOD, GSH and…
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