Biomarker-guided Implementation of Glutamine to Reduce AKI After Cardiac Surgery (L-Alanyl/L-Glutamine)
Cardiac Surgery · Acute Kidney Injury
Enrolment: 64 · Results not recorded
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Nutraceutical · ChEMBL mechanism recorded as Unknown; comment: L-glutamine may improve the NAD redox potential in sickle RBCs through increasing the availability of reduced glutathione.
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Cardiac Surgery · Acute Kidney Injury
Enrolment: 64 · Results not recorded
Trauma ICU Patients
Enrolment: 150 · Results not recorded
Trauma · Injury Severity Score > 12
Enrolment: 43 · Results not recorded
Inflammatory Response · Multi-organ Failure
Enrolment: 101 · Results not recorded
Systemic Inflammatory Response Syndrome
Enrolment: 60 · Results not recorded
Digestive Cancers
Enrolment not recorded · Results not recorded
Colorectal Neoplasms
Enrolment: 200 · Results not recorded
Cardiac Function
Enrolment: 60 · Results not recorded
Diabetes
Enrolment: 12 · Results not recorded
Childhood Malignant Fibrous Histiocytoma of Bone · Sarcoma
Enrolment: 0 · Results not recorded
Type 2 Diabetes
Enrolment: 22 · Results not recorded
Gastric Cancer
Enrolment: 34 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Acute cantharidin-induced cardiotoxicity, cantharidin in DMSO given intraperitoneally at 2 mg/kg (weight-loss experiment) or 3 mg/kg (survival, ECG, biomarker, histology and oxidative stress experiments)
L-glutamine pretreatment reduced cantharidin-induced weight loss and mortality, lowered the rise in cardiac mass index, attenuated ST segment elevation, significantly decreased serum CK, CK-MB, AST and LDH, reduced myocardial inflammatory infiltrate and interstitial hyperaemia, altered SOD, GSH and…
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Model: Single 10 Gy radiation session aimed at the pelvico-abdominal region, causing bladder wall injury
Radiation reduced lamina propria blood vessel density by 48 percent at day 7 (p < 0.05) and urothelial thickness by 25 percent at day 15 (p < 0.05), and glutamine largely prevented both changes (p < 0.02 and p < 0.01 respectively). Glutamine did not prevent the 35 percent increase in epithelial cel…
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Model: Acute heat stress by exposure to a high ambient temperature of 39 degrees C for 2 h, causing intestinal barrier dysfunction and bacterial translocation
Dietary glutamine supplementation attenuated heat-induced hyperthermia and prevented the increases in intestinal permeability and bacterial translocation, with no correlation between the two effects.
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