Transplantation of insulin-like growth factor-1 laden scaffolds combined with exercise promotes neuroregeneration and angiogenesis in a preclinical muscle injury model.
MouseWound129S1/SvImJMalen = 18 tibialis anterior muscles across 4 groups: scaffold with…Local implantation into the tibialis anterior defectScaffolds loaded by overnight incubation with 250 microgram…Scaffold implanted immediately after creation of the injury; voluntary wheel ru…
Model: Acute volumetric muscle loss created by surgical excision of 40 per cent of the tibialis anterior muscle, defect approximately 7 mm by 2 mm by 3 mm
In vitro, myotubes on IGF-1 scaffolds were longer (339 plus or minus 66 versus 204 plus or minus 14 micrometres) with more nuclei per myotube (9.5 plus or minus 1.7 versus 5.3 plus or minus 0.4). In vivo, IGF-1 scaffolds with exercise increased perfused vessel density more than 3-fold versus scaffo…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.