Harnessing the Secretome of Mesenchymal Stromal Cells for Traumatic Spinal Cord Injury: Multicell Comparison and Assessment of In Vivo Efficacy
RatSpinal cord injuryContusionWistarFemalen = n=4-5 per group (acute vascular pathology assays); n=7-10 p…Intravenous (tail vein)1 mL concentrated conditioned media per infusion (protein c…First infusion 7 minutes post-SCI
Model: C7-T1 clip compression/contusion spinal cord injury (35 g, 1 min)
Early intravenous HUCMC-derived secretome infusion (7 min post-SCI) significantly reduced acute (48 h) lesion volume and improved functional vascularity compared with bone marrow MSC and fibroblast secretomes; long-term (10 weeks), repeated infusion reduced cavity volume and increased myelin preser…
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