THERAPY DOSSIER · th-2275c0fa15ae

Concentrated conditioned media (secretome) from human umbilical cord matrix cells (HUCMCs), compared with bone marrow mesenchymal stromal cells and newborn/adult fibroblast secretome

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05008588 ↗PHASE1/PHASE2active not recruiting

Combined Conditioned Medium With UC-MSC for Acute Stroke Infarct

Ischemic Stroke

Enrolment: 15 · Results not recorded

NCT05579665 ↗PHASE1/PHASE2completed

PRP, UC-MSC Conditioned Medium Secretome and Hyaluronic Acid for Knee Osteoarthritis

Knee Osteoarthritis

Enrolment: 45 · Results not recorded

NCT07504822 ↗PHASE1/PHASE2not yet recruiting

Clindamycin-Retinoid Combinations and 10% SM-hUCMSC Secretome Gel in Mild-to-Moderate Acne Vulgaris

Acne Vulgaris

Enrolment: 189 · Results not recorded

NCT07439848 ↗PHASE1/PHASE2recruiting

MSC and Their Secretome as Adjuvant Therapy in Sepsis Due to Pneumonia

Acute Respiratory Distress Syndrome

Enrolment: 15 · Results not recorded

NCT06629909 ↗PHASE1not yet recruiting

Safety and Feasibility of Human UC-MSC-Derived Secretome in Liver Cirrhosis

Liver Cirrhosis

Enrolment: 54 · Results not recorded

NCT06638970 ↗PHASE1not yet recruiting

Clinical Utility and Safety of Human UC-MSC Secretome in Drug Resistant Epilepsy

Epilepsy · Drug Resistant Epilepsy

Enrolment: 54 · Results not recorded

NCT06632470 ↗PHASE1not yet recruiting

Clinical Utility and Safety of Human UC-MSC Secretome in Moderate Neurocognitive Impairment (Dementia)

Dementia · Moderate Dementia

Enrolment: 54 · Results not recorded

NCT06217627 ↗PHASE1completed

The Potential of Umbilical Cord Stem Cell Secretions in Skin Rejuvenation

Skin Rejuvenation

Enrolment: 49 · Results not recorded

NCT07245875 ↗NAcompleted

UC-MSC Secretome in Patients With Severe Erectile Dysfunction Non-responsive to Sildenafil

Erectile Dysfunction · Diabetes Mellitus Type 2

Enrolment: 12 · Results not recorded

NCT07731087 ↗NArecruiting

MSC Secretome Therapy on Cognitive Recovery in Subacute Ischemic Stroke

Ischemic Stroke · Post-Stroke Cognitive Impairment

Enrolment: 70 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32962528 ↗2020Mixed findings

Harnessing the Secretome of Mesenchymal Stromal Cells for Traumatic Spinal Cord Injury: Multicell Comparison and Assessment of In Vivo Efficacy

RatSpinal cord injuryContusionWistarFemalen = n=4-5 per group (acute vascular pathology assays); n=7-10 p…Intravenous (tail vein)1 mL concentrated conditioned media per infusion (protein c…First infusion 7 minutes post-SCI

Model: C7-T1 clip compression/contusion spinal cord injury (35 g, 1 min)

Early intravenous HUCMC-derived secretome infusion (7 min post-SCI) significantly reduced acute (48 h) lesion volume and improved functional vascularity compared with bone marrow MSC and fibroblast secretomes; long-term (10 weeks), repeated infusion reduced cavity volume and increased myelin preser…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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