Direct Peritoneal Resuscitation Improves Survival in a Murine Model of Combined Hemorrhage and Burn Injury
MouseHaemorrhage/shockControlledC57/BL6JMaleIntraperitoneal (DPR), combined with intravascular resuscitation using lactated Ringer solution or 1:1 packed red blood cells and fresh frozen plasma1.5 mL normal saline or 1.5 mL peritoneal dialysis solution…Administered following scald burn, before haemorrhage induction
Model: Combined 30% TBSA scald burn plus controlled haemorrhagic shock (femoral artery cannulation to SBP 25 mmHg for 30 min)
DPR with either normal saline or Delflex significantly improved median survival time after combined burn and haemorrhagic shock in mice compared with no DPR; DPR with normal saline reduced the inflammatory response and delayed acute lung injury progression compared with Delflex, while DPR combined…
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