Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Haemorrhage/shock
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 6
4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Phase I Clinical Trial Utilizing Direct Peritoneal Resuscitation in Liver Transplant Recipient Population at Increased Risk of Return to the Operating Room and Early Allograft Dysfunction
End Stage Liver DIsease · Obesity · Acute Kidney Injury
Enrolment: 15 · Results not recorded
Direct Peritoneal Resuscitation for Intra-abdominal Catastrophes
Intestinal Perforation · Intestinal Obstruction · Trauma Abdomen
Enrolment: 108 · Results not recorded
Direct Peritoneal Resuscitation Effects in the Damage Control Patient
Traumatic Injury
Enrolment: 7 · Results not recorded
Direct Resuscitation of the Open Peritoneum: A Randomized Controlled Trial in Non-Traumatic Patients
Wound; Abdomen · Abdomen, Acute · Wound Surgical
Enrolment: 200 · Results not recorded
A Comparison of Direct Peritoneal Resuscitation Plus Conventional Resuscitation Versus Conventional Resuscitation Alone in Patients Undergoing Hepatic Resection for Cancer
Hepatic Cancer
Enrolment: 0 · Results not recorded
Direct Peritoneal Resuscitation in Gastroschisis
Gastroschisis
Enrolment: 3 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseHaemorrhage/shockControlledC57/BL6JMaleIntraperitoneal (DPR), combined with intravascular resuscitation using lactated Ringer solution or 1:1 packed red blood cells and fresh frozen plasma1.5 mL normal saline or 1.5 mL peritoneal dialysis solution…Administered following scald burn, before haemorrhage induction
Model: Combined 30% TBSA scald burn plus controlled haemorrhagic shock (femoral artery cannulation to SBP 25 mmHg for 30 min)
DPR with either normal saline or Delflex significantly improved median survival time after combined burn and haemorrhagic shock in mice compared with no DPR; DPR with normal saline reduced the inflammatory response and delayed acute lung injury progression compared with Delflex, while DPR combined…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
