Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the Brain
MouseTBIWeight-drop / impact-accelerationCD-1Malen = n=6 mice per group (main cohort); n=5 per group (immunofluo…Intraperitoneal50 mg/kg body weight, intraperitoneal1 hour before TBI (prophylactic), then day 2 and day 4 after TBI
Model: Closed head weight-drop-induced acute traumatic brain injury (35 g weight, 80 cm drop)
Closed head weight-drop TBI caused astrogliosis, reduced neuronal (NeuN) levels, impaired novel object recognition, and decreased pericyte marker PDGFR-beta and tight junction proteins JAM-A and ZO-1 at 7 days; cromolyn administration significantly inhibited the TBI-induced decrease in PDGFR-beta,…
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