Novel Strategies for Reducing Burn Scar Itch (famotidine + topical cromolyn sodium)
Burn Scar · Itch Scarring · Wound
Enrolment: 44 · Results not recorded
Loading the evidence…
Drug · Unknown
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Burn Scar · Itch Scarring · Wound
Enrolment: 44 · Results not recorded
Exercise-Induced Bronchoconstriction
Enrolment: 8 · Results not recorded
Alzheimer's Disease
Enrolment: 620 · Results not recorded
Acute Stroke
Enrolment not recorded · Results not recorded
Amyotrophic Lateral Sclerosis (ALS)
Enrolment: 105 · Results not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 12 · Results not recorded
Asthma, Exercise-Induced
Enrolment: 62 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: unilateral patellar tendon injury
Sodium cromolyn improved collagen organisation and attenuated hypercellularity and thickening with downregulation of fibrosis genes.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Closed head weight-drop-induced acute traumatic brain injury (35 g weight, 80 cm drop)
Closed head weight-drop TBI caused astrogliosis, reduced neuronal (NeuN) levels, impaired novel object recognition, and decreased pericyte marker PDGFR-beta and tight junction proteins JAM-A and ZO-1 at 7 days; cromolyn administration significantly inhibited the TBI-induced decrease in PDGFR-beta,…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Paraquat-induced lung injury by single oral dose of paraquat 40 mg/kg
Lung hydroxyproline and serum IL-1 beta, TNF-alpha and IL-8 were significantly lower in cromolyn-treated rats than in the paraquat group, with the best response at 8 mg/kg and supporting histology.
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Orthotopic left lung allotransplantation with 5 hours cold plus 1 hour warm ischaemia, followed by weekly aspiration of gastric fluid for 8 weeks to induce obliterative bronchiolitis
No peri-operative mortality occurred in cromolyn-treated recipients versus 11 of 36 untreated recipients (p = 0.045). The mean fraction of airways affected by obliterative bronchiolitis fell from 0.456 plus or minus 0.068 to 0.108 plus or minus 0.030 (p < 0.001) and parenchymal fibrosis score from…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.