Ampakines stimulate phrenic motor output after cervical spinal cord injury.
RatSpinal cord injuryHemisection / partialSprague-DawleyMalen = n = 8 per group at each of the 2-week and 8-week time point…Intravenous, infused over 1 minute via tail vein catheter15 mg/kg (5 mg/ml in 10% 2-hydroxypropyl-beta-cyclodextrin)Single acute dose during terminal neurophysiology at 2 weeks or 8 weeks post-C2…
Model: Left C2 lateral spinal cord hemisection (C2Hx) via C2 laminectomy, studied at 2 or 8 weeks post-injury under urethane anaesthesia with bilateral phrenic nerve recording
Intravenous CX717 produced a rapid and sustained bilateral increase in phrenic inspiratory burst amplitude at both 2 and 8 weeks post-injury, and restored quantifiable ipsilateral bursting in rats with absent baseline output. Pairing with a single hypoxic bout was inconsistent, with variable enhanc…
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