Vitamin D3 analogue facilitates epithelial wound healing through promoting epithelial-mesenchymal transition via the Hippo pathway.
MouseWoundMaleEarly in the wound
Model: Acute excisional skin wound model in mice; scratch assay in HaCaT and normal human epidermal keratinocyte cells in vitro
Calcipotriol increased re-epithelialisation early in the wound and accelerated wound closure, an effect attributed to induction of epithelial-mesenchymal transition through regulation of the Hippo pathway. In vitro it promoted keratinocyte migration in scratch assays.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.