THERAPY DOSSIER · th-606dfc8e6626

Calcipotriol, a synthetic vitamin D3 analogue

Drug · Vitamin D receptor agonist

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Vitamin D receptor agonist
Target: CHEMBL1977
Injury models: Wound
Reported indication: Not recorded
First approval: 1993
Development stage: Not recorded
ChEMBL record: CHEMBL1200666 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Calcipotriene; Calcipotriol; Calcipotriol monohydrate; Dovobet; Dovonex; Enstilar; MC-903; PRI-2201; Sorilux; Taclonex; Xamiol
Note: Not recorded

Clinical trials 9

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03080545 ↗PHASE4completed

Enstilar (Calcipotriene/Betamethasone) Foam in Psoriasis Patients on Biologic Agents

Psoriasis

Enrolment: 25 · Results not recorded

NCT06499415 ↗PHASE4recruiting

5-Fluorouracil and Calcipotriol vs 5-Fluorouracil in Treatment of Actinic Keratosis

Actinic Keratoses

Enrolment: 232 · Results not recorded

NCT07453238 ↗PHASE4not yet recruiting

Topical Calcipotriol vs Intralesional Corticosteroids in Alopecia Areata

Alopecia Areata

Enrolment: 60 · Results not recorded

NCT01989429 ↗PHASE3completed

Phase III Trial Comparing M518101, Daivonex and Vehicle in Plaque Psoriasis

Plaque Psoriasis

Enrolment: 788 · Results not recorded

NCT00216879 ↗PHASE3completed

Long-term Treatment of Scalp Psoriasis With Calcipotriol Plus Betamethasone Dipropionate Gel

Psoriasis of Scalp

Enrolment: 800 · Results not recorded

NCT01347255 ↗PHASE2completed

A Psoriasis Plaque Test Study With LEO 90100 Cutaneous Spray in Psoriasis Vulgaris

Psoriasis Vulgaris

Enrolment: 24 · Results not recorded

NCT07410793 ↗PHASE2recruiting

Acupuncture With Herbal Cream vs Acupuncture With Calcipotriol for Plaque Psoriasis

Plaque Type Psorisis

Enrolment: 28 · Results not recorded

NCT03848806 ↗PHASE2completed

Phase II Trial of HAT1 Compared to Calcipotriol in Mild to Moderate Chronic Plaque Psoriasis

Psoriasis

Enrolment: 174 · Results not recorded

NCT04440371 ↗NAunknown

Tacrolimus vs Calcipotriol/Betamethasone With NBUVB in Treatment of Vitiligo

Vitiligo, Generalized

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32938565 ↗2020Reported benefit

Vitamin D3 analogue facilitates epithelial wound healing through promoting epithelial-mesenchymal transition via the Hippo pathway.

MouseWoundMaleEarly in the wound

Model: Acute excisional skin wound model in mice; scratch assay in HaCaT and normal human epidermal keratinocyte cells in vitro

Calcipotriol increased re-epithelialisation early in the wound and accelerated wound closure, an effect attributed to induction of epithelial-mesenchymal transition through regulation of the Hippo pathway. In vitro it promoted keratinocyte migration in scratch assays.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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