Polydatin Attenuates 14.1 MeV Neutron-Induced Injuries via Regulating the Apoptosis and Antioxidative Pathways and Improving the Hematopoiesis of Mice.
MouseRadiationWild-type Balb/cMalen = Survival study: 24 mice randomised to 3 groups, 8 per group…Intraperitoneal injection100 mg/kg in 0.1 ml of 5% DMSOPretreatment starting one day before irradiation
Model: Acute radiation syndrome from a single whole-body dose of 14.1 MeV monoenergetic fast D-T fusion neutrons generated by the HINEG generator, at calculated absorbed doses of 0.64, 0.95, 1.54 and 2.91 Gy with approximately 5% gamma contamination
At 2.91 Gy, polydatin raised 30-day survival from approximately 50% with vehicle to 100%, and reduced body weight loss, spleen and testis index decline, bone marrow and splenic microstructural damage, splenocyte apoptosis and peripheral blood cell declines, with increased Bcl-2 and HO-1.
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