HW6 (Polydatin Injectable) in Traumatic/Hemorrhagic and Septic Shock
Shock, Hemorrhagic · Shock, Traumatic · Shock, Septic
Enrolment: 240 · Results not recorded
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Nutraceutical
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Shock, Hemorrhagic · Shock, Traumatic · Shock, Septic
Enrolment: 240 · Results not recorded
Irritable Bowel Syndrome
Enrolment: 60 · Results not recorded
Irritable Bowel Syndrome
Enrolment: 70 · Results not recorded
Endometriosis · Chronic Pelvic Pain
Enrolment: 30 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Acute radiation syndrome from a single whole-body dose of 14.1 MeV monoenergetic fast D-T fusion neutrons generated by the HINEG generator, at calculated absorbed doses of 0.64, 0.95, 1.54 and 2.91 Gy with approximately 5% gamma contamination
At 2.91 Gy, polydatin raised 30-day survival from approximately 50% with vehicle to 100%, and reduced body weight loss, spleen and testis index decline, bone marrow and splenic microstructural damage, splenocyte apoptosis and peripheral blood cell declines, with increased Bcl-2 and HO-1.
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
Model: Lipopolysaccharide (LPS)-induced acute lung injury
Polydatin upregulated Clara cell secretory protein and suppressed phospholipase A2 in LPS-induced lung injury.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Radiation-induced lung injury from a single 15 Gy whole-thorax irradiation (cobalt-60 source, 1 Gy/min), followed to 16 weeks; supporting in vitro work in BEAS-2B human bronchial epithelial cells irradiated at 8 Gy
Polydatin reduced pulmonary congestion, oedema and lung coefficient, lowered early inflammation and late collagen deposition and hydroxyproline, inhibited epithelial-mesenchymal transition and TGF-beta1-Smad3-Snail signalling, and corrected the Th1/Th2 cytokine shift. Radioprotection depended on Si…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Thermal burn covering 30 percent total body surface area followed by resuscitation, with secondary acute lung injury
Polydatin reduced pulmonary microvascular permeability, wet-to-dry ratio, myeloperoxidase activity, pro-inflammatory cytokines and apoptosis after burn injury.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.