Crocin ameliorates arsenic trioxide-induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.
RatChemical/toxinSprague-Dawleymalen = 48 male ratsGiven in combination with arsenic trioxide
Model: Arsenic trioxide-induced cardiotoxicity in rats
Crocin reduced QTc prolongation, myocardial enzyme and troponin T levels, improved histopathology, lowered reactive oxygen species, malondialdehyde and proinflammatory cytokines, raised antioxidant enzyme levels, reduced caspase-3 and Bax and increased Bcl-2, with activation of Nrf2 signalling.
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