The Effect of Crocina on The Cellular Immune Responses in Patients With Osteoarthritis as Randomized, Double-blind and Placebo Controlled
Osteoarthritis, Knee
Enrolment: 40 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Osteoarthritis, Knee
Enrolment: 40 · Results not recorded
Chorioretinopathy, Central Serous
Enrolment: 40 · Results not recorded
Dry Eye · Meibomian Gland Dysfunction · Dry Eye Syndromes
Enrolment: 25 · Results not recorded
Breast Cancer
Enrolment: 120 · Results not recorded
Type 2 Diabetes
Enrolment: 50 · Results not recorded
Parkinson Disease · Neurodegenerative Diseases
Enrolment: 120 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Arsenic trioxide-induced cardiotoxicity in rats
Crocin reduced QTc prolongation, myocardial enzyme and troponin T levels, improved histopathology, lowered reactive oxygen species, malondialdehyde and proinflammatory cytokines, raised antioxidant enzyme levels, reduced caspase-3 and Bax and increased Bcl-2, with activation of Nrf2 signalling.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Haemorrhagic shock followed by resuscitation
Crocin given during resuscitation improved organ injury markers and reduced malondialdehyde and myeloperoxidase while increasing glutathione, consistent with an antioxidant protective effect.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.
Model: Acute zearalenone-induced cardiotoxicity, with zearalenone administered at 40 mg/kg body weight
Zearalenone raised cardiac injury enzymes and lipids, induced oxidative stress and Hsp70 expression, and triggered apoptosis in cardiac tissue. Combined treatment with crocin at 50, 100 and 250 mg/kg produced a significant, dose-dependent reduction of zearalenone-induced toxicity across all tested…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.